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Lariam tablets contain the active ingredient mefloquine. Lariam is used to treat malaria and to help prevent you from catching malaria.
Malaria is a life threatening disease and a major health risk for travellers visiting tropical countries.
It occurs when small parasites are passed from one person to another by the bites of certain mosquitoes. Lariam is especially useful if you are travelling to countries where there is a type of malaria which is particularly difficult to treat. No single medicine is effective against all malaria parasites. The choice of a particular medicine depends on the sensitivity of the malaria parasites found in the area to be visited. Your doctor will advise you whether Lariam is suitable for the area to which you wish to go.
To help minimise your chance of catching the disease and to protect you from possible serious side effects it is important that you read this leaflet carefully. Ask your doctor to explain anything you do not understand.
What you need to know before you take Lariam
Do not take Lariam if you have or have previously experienced:
If any of the above applies to you, make sure your doctor knows, so that your doctor can prescribe a different medicine for prevention or treatment of malaria.
Also, consult your doctor immediately if you are already being treated with halofantrine, or you have been prescribed a course of halofantrine. Halofantrine (which is used to treat malaria) and Lariam taken at the same time can slow the heartbeat to a dangerous level. Therefore, to help avoid the possibility of a dangerous alteration in heart rhythm, you must not take halofantrine if you are already taking, or have taken Lariam within the last 15 weeks.
Warnings and precautions
Lariam may cause serious mental problems in some people. Tell your doctor immediately if you experience any of the following while taking Lariam:
Please seek medical help immediately if you experience serious mental problems while taking Lariam. Lariam should be stopped immediately and replaced with another medicine to prevent malaria.
Talk to your doctor, pharmacist, or nurse before taking Lariam if you have:
Some side effects may occur after you have stopped taking Lariam. In a small number of patients it has been shown that depression, dizziness or vertigo and loss of balance may persist for months or longer, even after you have stopped taking Lariam.
Children
Experience with Lariam in infants less than 3 months old or weighing less than 5 kg is limited.
Other medicines and Lariam
Before taking Lariam, make sure your doctor knows if you are taking other medicines (including those you have obtained without a prescription).
Tell your doctor, pharmacist, or nurse if you are taking, have recently taken or might take any other medicines including:
If you need an oral vaccine to help prevent you from catching typhoid, you should arrange to receive it at least 3 days before you need to start taking Lariam. Otherwise, Lariam may stop the vaccine from working properly.
Pregnancy and breast-feeding
Pregnant women should not normally take these tablets.
Due to the seriousness of malaria during pregnancy, it is recommended that you should not travel to an area where you could become infected with malaria if you are pregnant, think that you may be pregnant, or if you are planning to have a baby.
Lariam should be avoided by women who are breast-feeding.
If you are pregnant or breast-feeding, think that you may be pregnant, or planning to have a baby, ask your doctor for advice before taking this medicine, as he or she may decide that you should not use this medicine.
Driving and using machines
Take special care if you perform activities requiring alertness and coordination (accurate small movements) and spatial awareness (being aware of distances) such as driving, piloting an aircraft, operating machinery, cycling, and deep-sea diving as Lariam can cause dizziness, loss of balance and mental problems. If you are in any doubt about whether you can do a particular activity, talk to your doctor.
In a small number of patients it has been shown that dizziness, vertigo and loss of balance may persist for months or longer after stopping Lariam.
Lariam contains lactose
If you have been told by your doctor that you have an intolerance to some sugars, such as lactose or galactose, you should not take Lariam. Contact your doctor before taking this medicinal product.
Always take this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. The advice you are given will depend on whether you are taking the tablets for prevention or treatment of malaria. Take the tablets with plenty of water, and preferably after a meal. Swallow the tablets whole, do not suck or chew them.
Malaria prevention
Please read the following section if you are taking the tablets to help prevent you from catching malaria.
Important
Adults and children over 45 kg body weight, dose:
One tablet weekly (always on the same day).
A pack of 8 tablets is enough to help prevent you from catching malaria if you are staying for 2 weeks in an area where malaria is present and you start taking the tablets at 10 days and 3 days before departure.
Adults weighing less than 45 kg (99 lbs) should take the children’s dose (see below).
Whether you are an adult or a child you should not take the tablets for more than 12 months.
Childrens dose:
The tablets are not recommended for children under 3 months of age, i.e., those who weigh less than 5 kg (11 lbs). For children over this weight, the dose is shown in the table below. The tablets can be divided by breaking along the score lines. As in adults, the dose should be taken once weekly on the same day, and continued for 4 weeks after return.
For children of an approximate age of 3 months to 5 years, weighing between 5-19 kg (11-43 lbs) the recommended dose is ¼ tablet.
For children of an approximate age of 6 to 8 years, weighing between 20-30 kg (44-67 lbs) the recommended dose is ½ tablet.
For children of an approximate age of 9 to14 years, weighing between 31-45 kg (68-99 lbs) the recommended dose is ¾ tablet.
Malaria treatment
Please read the following section if you are taking the tablets to treat malaria.
Your doctor will tell you how much medicine you need to take. This will depend on your weight and whether you have been living in a malarious area. Normally, you should not receive more than 6 tablets in total. You may be advised to split the total dose into 2 or 3 smaller doses, 6 - 8 hours apart, to reduce the likelihood or severity of side effects.
If you take more Lariam than you should, either for prevention or treatment
If you take too many tablets the likelihood and severity of the side effects as described in section 4 may increase. There are no specific antidotes.
If you take too many tablets or someone else accidentally takes your medicine, contact your doctor, pharmacist or nearest hospital immediately.
If you forget to take Lariam, either for prevention or treatment
If you miss a dose, take it as soon as possible. If it is nearly time for your next dose, skip the missed dose and carry on as before. Do not take a double dose.
Like all medicines, this medicine can cause side effects although not everybody gets them.
Lariam may cause serious mental problems in some people. Stop taking this medicine and contact your doctor immediately if you experience any of the following while taking Lariam:
Common (may affect up to 1 in 10 people):
Not known (frequency cannot be estimated from the available data):
Please seek medical help immediately if you experience serious mental problems while taking Lariam. Lariam should be stopped immediately and replaced with another medicine to prevent malaria.
If you develop any of the following potentially serious symptoms, you should STOP taking this medicine and also consult a doctor immediately.
Not known (frequency cannot be estimated from the available data):
Other possible side effects
Very common (may affect more than 1 in 10 people):
Common (may affect up to 1 in 10 people):
Not known (frequency cannot be estimated from the available data):
Whilst taking this medicine, if you experience these or any other symptoms that concern you, tell your doctor.
Some side effects may occur after you have stopped taking Lariam. In a small number of patients it has been shown that depression, dizziness or vertigo and loss of balance may persist for months or longer, even after you have stopped taking Lariam.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
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